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Short answer: PT-141 (bremelanotide) acts directly on desire centres in the brain and works within hours. Its injection form was approved in the US in 2019 for low sexual desire in premenopausal women. Kisspeptin works one step earlier: it signals the brain to release the hormones that drive testosterone and fertility, and small studies show it also strengthens sexual and emotional brain responses. PT-141 is taken when needed, while Kisspeptin is usually part of a hormone plan. Low desire often has a medical cause, so a physician should check hormones, medicines and mood first.
Key facts
| PT-141 (Bremelanotide) | Kisspeptin-10 | |
|---|---|---|
| How it works | Activates melanocortin receptors in the brain linked to desire | Triggers release of GnRH, then LH and FSH, which drive testosterone and fertility |
| How it is used | On demand, about 45 minutes or more before intimacy | Usually a planned course set by a physician |
| Approval | US FDA approved (2019) for low desire in premenopausal women | Research use; studied in fertility and hormone clinics |
| Main side effects | Nausea, flushing, headache, short rise in blood pressure | Generally mild in studies; hormone levels need checking |
| Our product | PT-141 20 mg, 2 ml pen, 1,800 SAR | Kisspeptin-10 3 mg pen, 2,175 SAR |
What is PT-141?
PT-141 was developed from Melanotan II, a tanning peptide, after researchers noticed that it increased sexual arousal. Unlike tablets such as sildenafil, which improve blood flow, PT-141 works in the brain on the pathways that create desire. In two large trials in women with low desire, it improved desire and reduced distress compared with placebo, which led to US approval under the name Vyleesi. In men it has been studied for erectile difficulties, including in men who did not respond to tablets, but it is not approved for men.
About four in ten women in the trials had nausea, usually after the first doses. It can briefly raise blood pressure, so it is not suitable for people with uncontrolled high blood pressure or heart disease. It should not be used more than once in 24 hours.
What is Kisspeptin?
Kisspeptin is a natural hormone made in the hypothalamus. It is the "on switch" for the reproductive hormone system in both men and women. Researchers at Imperial College London have shown that a Kisspeptin infusion increased LH and testosterone in men and, in brain scans, increased activity in areas linked to attraction and sexual response. A 2023 study found similar effects in women and men with low desire. It is also studied as a gentler trigger for egg release in IVF.
Kisspeptin is of most interest to men with low-normal testosterone who want to keep their own production and fertility, and to people whose low desire may be linked to hormones. See also hCG for men: testosterone and fertility.
Which one is right for me?
- Desire is low but hormones are normal: PT-141 may be considered.
- Low energy, low libido and low-normal testosterone: Kisspeptin or hCG may be considered after blood tests.
- Erection problems only: standard tablets are usually the first step. Heart health should be checked, as erection problems can be an early sign of heart disease.
Check the cause first
Low desire is common and has many causes: stress, poor sleep, depression, relationship strain, thyroid problems, low testosterone, menopause, diabetes and medicines such as some antidepressants. A good consultation looks at all of these. Many people improve once the underlying cause is treated, without any peptide. Our guide to your first consultation explains what is checked.
Common questions
Is PT-141 like Viagra?
No. Viagra-type tablets improve blood flow. PT-141 acts on desire in the brain. They are sometimes used together under a physician's care.
How fast does PT-141 work?
The approved product is taken at least 45 minutes before intimacy, and effects can last several hours.
Does Kisspeptin increase testosterone?
In studies it raised LH and testosterone in men within hours. Long-term effects of repeated use are still being studied.
Can women use Kisspeptin?
Yes, it has been studied in women, including for low desire and fertility treatment. It should not be used during pregnancy.
Is my consultation private?
Yes. Consultations are confidential and handled by a licensed physician.
Information on this website is for education only and does not replace a physician's advice. Treatments are dispensed by prescription only, after assessment by a licensed physician.
Keep reading
- hCG for men: testosterone and fertility
- Your first peptide consultation
- Peptide side effects
- Hormone and reproductive peptides
Book a private consultation to discuss desire, hormones or fertility.