Cart
0
Short answer: KPV is a tiny peptide of three amino acids (lysine, proline, valine) taken from the end of alpha-MSH, a natural hormone that calms inflammation. In animal and cell studies it reduced inflammation in the gut lining and the skin. There are no completed human trials yet, so it is an experimental option, not a treatment for conditions such as Crohn's disease or ulcerative colitis. A physician may consider it as an add-on, never as a replacement for proven care.
Key facts
- Structure: three amino acids, Lys-Pro-Val.
- Origin: the last three amino acids of alpha-melanocyte stimulating hormone (alpha-MSH).
- Main research areas: inflammatory bowel disease models, skin inflammation and wound healing.
- Evidence level: cell and animal studies only.
- Our products: KPV 10 mg, 3 ml prefilled pen (1,950 SAR) and the KLOW blend (5,685 SAR).
How does KPV work?
Alpha-MSH is best known for skin colour, but it also switches off inflammation. Researchers found that its last three amino acids keep much of the anti-inflammatory effect without affecting pigment. In cells, KPV enters through a transporter called PepT1, which is more active in an inflamed gut, and it reduces the NF-kB signal that drives inflammation. In mouse models of colitis, KPV given by mouth or by injection reduced inflammation and tissue damage.
What the evidence does not show yet
Mouse colitis is not the same as human disease, and many treatments that work in mice fail in people. KPV has not been tested in a published human trial for IBD, irritable bowel syndrome, eczema or any other condition. Anyone who has a diagnosed inflammatory disease should keep their specialist in charge of treatment.
See your doctor promptly if you have blood in your stool, night-time diarrhoea, unexplained weight loss, anaemia or a family history of bowel cancer. These need investigation, not a peptide.
What is the KLOW blend?
KLOW combines four peptides in one pen: BPC-157 6 mg, Thymosin Beta-4 6 mg, GHK-Cu 30 mg and KPV 6 mg. The idea is to pair tissue-repair peptides with an anti-inflammatory one, mainly for recovery, skin and gut support. It is the most complete of our stacks. Compare it with the Wolverine and Glow stacks in Wolverine vs Glow vs KLOW.
KPV vs BPC-157 for the gut
| KPV | BPC-157 | |
|---|---|---|
| Main action | Calms inflammation | Supports tissue repair and blood supply |
| Origin | Fragment of alpha-MSH | Based on a protein in stomach juice |
| Research | Colitis and skin models in animals | Many animal studies on gut, tendon and muscle |
| Human trials | None published | Very few, small |
Read more in BPC-157 and TB-500: what the research actually shows.
Safety
Because KPV is a small fragment of a natural hormone, it is expected to be well tolerated, and animal studies did not show major problems. Human safety data are lacking. It should be avoided in pregnancy and breastfeeding, and used with care by people on immune-suppressing medicines.
Common questions
Can KPV cure IBS or colitis?
No. There is no human evidence that KPV treats any gut disease. It may be considered as an add-on by a physician, alongside standard care.
Does KPV affect skin colour like Melanotan?
No. KPV lacks the part of alpha-MSH that darkens the skin.
Is KPV taken by mouth or injection?
Both have been studied in animals. Our KPV is a prefilled pen for injection under the skin, at a dose set by your physician.
Is KLOW better than KPV alone?
Not necessarily. KLOW suits people who want recovery and skin support too. If inflammation is the only goal, KPV alone is simpler and cheaper.
Information on this website is for education only and does not replace a physician's advice. Treatments are dispensed by prescription only, after assessment by a licensed physician.
Keep reading
- BPC-157 and TB-500: what the research shows
- Wolverine vs Glow vs KLOW: which peptide stack?
- Thymosin Alpha-1: the immune peptide
- Healing and skin peptides
Book a consultation to discuss gut or inflammation goals with a physician.